Medically reviewed by the Medical Director, Cupid Clinics. Last reviewed: October 2026.
Quick answer: PEP (post-exposure prophylaxis) is a 28-day course of HIV medicines that can prevent infection after a possible exposure. It must start within 72 hours, and the sooner the better, ideally within the first few hours. After 72 hours it is not recommended. If you’re inside that window, call a doctor now rather than waiting for a test.
A condom slipped, you had sex with someone whose status you don’t know, or you had a needle-stick injury at work. Panic is a normal reaction. The good news is that there is a proven way to lower your risk, and time is on your side if you act quickly.
What exactly is PEP?
PEP is a combination of antiretroviral medicines taken every day for 28 days. It stops HIV from establishing itself in the body if it entered during the exposure. In India, the national (NACO) guidelines recommend a once-daily combination tablet for most adults.
Why the 72-hour limit matters
In the first hours after exposure, HIV is still trying to take hold. PEP works best before that happens. Every hour counts, which is why we treat PEP calls as urgent, including through online consultation.
Do I need PEP?
A doctor decides based on what happened. PEP is usually advised after:
- Condomless vaginal or anal sex, or a condom breaking, with a partner who has HIV or whose status is unknown
- Sharing needles or injecting equipment
- Sexual assault
- Needle-stick or blood exposure at work
It is usually not needed after kissing, oral sex without other risk factors, or contact with saliva, sweat or urine. If you’re unsure, our private risk assessment can guide you, but if you’re within 72 hours, call us directly.
What happens at a PEP consultation?
- A confidential conversation about the exposure, with no judgement.
- A baseline HIV test and a few blood tests to check suitability.
- Your first dose, as soon as possible.
- A plan for follow-up HIV testing after the course.
Side effects
Modern PEP is generally well tolerated. Some people have mild nausea, tiredness or headache in the first days. Finish the full 28 days even if you feel fine; stopping early reduces protection.
PEP vs PrEP
PEP is for emergencies, after an exposure. PrEP (pre-exposure prophylaxis) is taken regularly before possible exposures by people at ongoing risk. If you’ve needed PEP more than once, ask us whether PrEP suits you. Read more on our PEP and PrEP page.
Frequently asked questions
Can I get PEP after 72 hours?
No, it’s not recommended after 72 hours. Instead, plan testing at the right time; see our guide to the HIV window period.
How effective is PEP?
Started early and taken fully, PEP greatly reduces the chance of HIV infection, though no method is 100 percent.
Will anyone else find out?
No. Your consultation and results are confidential and shared only with you.
Can I start PEP through an online consultation?
Yes. Our doctors can assess you online and guide you to start quickly in Bengaluru, Mangaluru or wherever you are.
Within 72 hours? Call now
Call Cupid Clinics on +91 95912 52505 for a confidential PEP consultation in Bengaluru, Mangaluru or online.
